Synonym(s): - Dermatostomatitis, Stevens Johnson type
Classification (Orphanet): - Rare skin disease Entire classification		Classification (ICD10): - Diseases of the skin and subcutaneous tissue - See
Epidemiological data: Class of prevalence: unknown Average age onset: variable Average age of death: - Type of inheritance: sporadic		External references: 1 OMIM reference - See 1 MeSH reference: D013262
More Info - Orphanet

Gene symbol	UniProt reference	OMIM reference
HLA-B	P30464	142830

- Asthenia / fatigue / weakness
- Enanthema / aphtosa / aphta / leukoplakia
- Erythema / erythematous lesions / erythroderma / polymorphous erythema
- Fever / chilling
- Macules
- Malabsorption / chronic diarrhea / steatorrhea
- Nausea / vomiting / regurgitation / merycism / hyperemesis
- Positive Nikolski's sign / achantolysis
- Vesicles / bullous / exsudative lesions / bullous / cutaneous / mucosal detachment
- Weight loss / loss of appetite / break in weight curve / general health alteration

- Feeding disorder / dysphagia / swallowing / sucking disorder / esophageal dyskinesia
- Hypersialorrhea
- Polynuclear cells / neutrophils anomalies / neutropenia

- Abnormal hepatic enzymes / transaminases
- Abnormal pleura / hydrothorax / pleuresia / pleural effusion / chylothorax
- Acute abdominal pain / colic
- Acute hepatic failure
- Anaemia
- Angor pectoris / myocardial infarction
- Chronic uveitis / blepharitis / episcleritis / scleritis / conjonctivitis / keratitis
- Collapse / sudden death / cardiac arrest / cardiorespiratory arrest
- Corneal ulceration / perforation
- Cough
- Dyspareunia / coital pain / vaginal dryness
- Ectropion / entropion / eyelid eversion
- Gastroesophageal reflux / pyrosis / esophagitis / hiatal hernia / gastroparesia
- Gastrointestinal bleeding / hemorrhage / hematemesis / melena / rectorrhagia
- Interstitial / restrictive pneumopathy / restrictive respiratory syndrome
- Intestinal perforation
- Myocardium anomalies / myocarditis
- Pancreatitis
- Phimosis / preputial adhesions / paraphimosis
- Photophobia
- Pollakiuria / polyuria / dysuria / anuria / acute urine retention / oliguria
- Renal failure
- Repeat respiratory infections
- Respiratory distress / dyspnea / respiratory failure / lung volume reduction
- Sepsis severe / septicemia
- Thirst
- Thrombocytopenia / thrombopenia
- Urethral anomalies / stenosis / posterior urethral valves / megalocystis
- Visual loss / blindness / amblyopia